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2004
LSU-HHMI Summer Undergraduate Research Program |
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 Amanda
R. Aguilar, (University of Texas – Pan American) Robert
Hammer, Chemistry.
Synthesis of Chiral α, αAmino Acids and their
incorporation into Model Hairpin Sequences
Chiral α, α-amino acids (ααAAs) are a key factor in the stabilization
of α-strand conformations of peptides. It is possible that the
R group of an amino acid may be able to further stabilize interactions
in α-sheets. This is in part due to the close proximity of the
side-chains to the amino acid residues. Also, the R groups on
one strand could potentially interact with the R groups on the
opposing strand, further stabilizing the conformation of the
α-sheet. This added stabilization is accomplished through interactions
in a pseudo diagonal interaction. In this study, chiral α,α-amino
acids were synthesized, and upon future research will be incorporated
into α-sheets.
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