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My research is utilizing physiological, cellular and molecular biological approaches
to study the adaptive mechanisms of solute homeostasis in fish during environmental
stress. Maintenance of solute balance at appropriate levels is of fundamental
importance in biology. Impairment of solute homeostasis is associated with a
variety of environmental disturbances (e.g., metal exposure, acidification,
osmotic challenges) and pathological states. The long-term focus of my research
is to identify and functionally characterize homeostatic mechanisms allowing
fish and other aquatic organisms to survive exposure to diverse aquatic environments.
My prospective research will address the following broad questions:
What adaptive features of fish epithelia influence tolerance to extreme
aquatic environments? Physiological, biochemical and molecular genetic aspects.
( Click
for details )
What adaptive features influence metal homeostasis during environmental perturbations? ( Click for details )
What are the biotic and abiotic determinants of metal bioavailability to fish in natural aquatic systems? ( Click for details )
Galvez, F., Wong, D. and Wood, C.M. Cd uptake in isolated mitochondria-rich cell populations from the gills of the freshwater rainbow trout. American Journal of Physiology (In press). ( pdf )
Hawkings, G.S., Galvez, F. and Goss, G.G. (2004). Seawater acclimation causes independent alterations in Na+/K+ and H+-ATPase activity in isolated MR cell sub-types of the rainbow trout gill: Re-evaluation of the trout gill model. Journal of Experimental Biology. 207: 905-912. [Featured in Inside JEB (2004), 207: 893]. ( pdf )
Reid, S.D., Hawkings, G.S., Galvez, F. and Goss, G.G. (2003). Localization and characterization of sodium influx in isolated rainbow trout gill epithelial cells. Journal of Experimental Biology. 206: 551-559. ( pdf )
Galvez, F. and Wood, C.M. (2002). The mechanisms and costs of physiological and toxicological acclimation to waterborne silver in juvenile rainbow trout. Journal of Comparative Physiology B. 172: 587-597. ( pdf )
Stafford, J.L., Galvez, F., Goss, G.G. and Belosevic M. (2002).
Induction of nitric oxide and respiratory burst response in activated goldfish
macrophages requires potassium channel activity. Developmental and Comparative
Immunology. 25: 445-459. ( pdf )
Galvez, F., Reid, S.D., Hawkings, G.S. and Goss, G.G. (2002).
Isolation and characterization of mitochondria-rich cell types from the gill
of freshwater rainbow trout. American Journal of Physiology. 282: R658-R668.
[Featured in Outside JEB (2003), 206: 7]. ( pdf )