Mutations are detected using various test systems in Drosophila and dose-response curves are contstructed. The nature of the mutational lesion is determined by comparing mutant alleles of the Adh locus with cloned DNA of this locus.
Lee, W. R. 1990. The importance of dosimetry and analysis of mutations for estimation of genetic risk. Mut. Res. 231:3-9.
Fossett, N. G., B. J. Byrne, S. J. Kelley, A. B. Tucker, P. Arbour-Reily and W. R. Lee. 1994. The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post- meiotic germ cells. Mut. Res. 307: 213-222.
Chenevert, S. W., N. G. Fossett, S. H. Chang, I. Tsigelny, M. E. Baker, and W. R. Lee. 1995. Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase null mutations. Biochem. J. 308: 419-423.
Drost, J. B. and W. R. Lee. 1995. Biological basis of germline mutation: Comparisons of spontaneous germline mutation rates among Drosophila, mouse and human. Environ. Mol. Muta. 25: Suppl. 26: 48-64.
Fossett, N. G., B. J. Byrne, A. B. Tucker, P. Arbour-Reily, S. Chang, and W. R. Lee. 1995. Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells. Mut. Res. (in press).