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Department
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Biochemistry and Molecular Biology is one of three divisions in the
Department of Biological Sciences at Louisiana State University. Degree
programs are offered in Biochemistry, Microbiology, Plant Biology
and Zoology. The diverse interests of the faculty facilitate advanced
study of prokaryotic and eukaryotic molecular biology, molecular genetics,
enzymology, and physical biochemistry. Visit our website (http://www.biology.lsu.edu)
for additional detail or contact the faculty member whose interests
most closely parallels yours about opportunities in this exciting
field of biological research.
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Graduate
Faculty
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Adjunct
Faculty |
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Konstantin G. Kousoulas, Adjunct Professor; Ph.D.,
Pennsylvania State University, 1981. Molecular biology of
herpes viruses.
Randall Mynatt, Adjunct Assistant Professor; Ph.D., University
of Tennessee, Knoxville, 1991. Obesity, transgenics.
Steven R. Smith, Adjunct Assistant Professor; M.D., University
of Texas Health Science Center, 1988. Adipocyte biology, energy
expenditure, metabolism
Jianping Ye
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Fareed Aboul-ela, Assistant Professor;
Ph.D., University of California 1988 faboul@lsu.edu
NMR, RNA Structure, Small-molecule RNA interactions.
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Lentzen, G., Klinck, R., Matassova, N., Aboul-ela, F.,
and Murchie, A. I. H. 2003. Structural basis for contrasting
activities of ribosome-binding thiazole antibiotics. Chemistry
& Biology. 10(8): 769-778.
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Davis, B., Afshar, M., Varani, G., Murchie, A. I. H.,
Karn, J., Lentzen, G, Drysdale, M. J., Bower, J., Potter,
A. J., Starkey, I. D., Swarbrick, T. M., and Aboul-ela,
F. 2004. Moulding RNA conformation by stabilisation of
electrostatic "hot spots"; how ligand-induced
conformational change in RNA mediates specific interaction.
Journal of Molecular Biology. 336: 343-356.
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Murchie, A. I. H., Davis, B., Isel, C., Afshar, M., Drysdale,
M. J., Bower, J., Potter, A. J., Starkey, I. D., Swarbrick,
T. M., Mirza, S., Prescott, C. D., Vaglio, P., Aboul-ela,
F., and Karn, J. 2004. Structure-based drug design targeting
an inactive conformation: exploiting the flexibility of
HIV-1 TAR RNA Journal of Molecular Biology. 336: 625-638. |
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Eric C.
Achberger, Associate Professor; Ph.D., The
Pennsylvania State University, 1978. eachber@lsu.edu
Biochemical and genetic analysis of
protein-DNA interactions in transcription initiation and
DNA restriction.
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Beary, T. P., H. D. Braymer and E.
C. Achberger. 1997. Evidence of participation of McrBS
in McrBC restriction in Escherichia coli K-12. J.
Bacteriol. 179:7768-7775.
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Silverman, H., S. J. Nichols, J. S.
Cherry, E. C. Achberger, J. W. Lynn, and T. H. Dietz.
1997. Clearance of laboratory-cultured bacteria by
freshwater bivalves: difference between lentic and lotic
unioids. Can. J. Zool. 75:1857-1866.
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| Nickerson C.A. and E.C. Achberger.
1995. RNA Polymerase from Escherichia coli Structures
the Promoter in the Presence of Curved DNA. J.
Bacteriol. 177:5756-5761. |
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Mark A. Batzer, Dr. Mary Lou Applewhite Distinguished Professor; Ph.D., Louisiana State
University, 1988. mbatzer@lsu.edu
Comparative Genomics, Molecular
Genetics, Mobile Element Biology, Computational Biology,
Human Genetics.
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| Han, K.*, J. Xing*, H. Wang, D. J. Hedges, R. K. Garber, R. Cordaux and M. A. Batzer (2005) Under the genomic radar: the stealth model of Alu amplification. Genome Research 15: 655-664 [cover article] |
Wang, H.*, J. Xing*, D. Grover*, D. J. Hedges, K. Han, J. A. Walker and M. A. Batzer (2005) SVA elements: a hominid specific retroposon family. Journal of Molecular Biology 354: 994-1007 [cover article] |
Xing, J.*, H. Wang*, V. P. Belancio, R. Cordaux, P. L. Deininger and M. A. Batzer (2006) Emergence of primate genes by retrotransposon-mediated sequence transduction. Proceedings of the National Academy of Sciences, USA 103: 17608-17613 [cover article] |
Sen, S. K.*, K. Han*, J. Wang, J. Lee, H. Wang, P. A. Callinan, M. Dyer, R. Cordaux, P. Liang and M. A. Batzer (2006) Human genomic deletions mediated by recombination between Alu elements. American Journal of Human Genetics 79: 41-53
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Han, K.*, M. K. Konkel*, J. Xing*, H. Wang*, J. Lee, T. J. Meyer, C. T. Huang, E. Sandifer, K. Hebert, E. W. Barnes, R. Hubley, W. Miller, A. F. A. Smit, B. Ullmer and M. A. Batzer (2007) Mobile DNA in Old World monkeys: a glimpse through the rhesus macaque genome. Science 316: 238-240 [cover article] |
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Rhesus Macaque Genome Sequencing and Analysis Consortium (2007) Evolutionary and biomedical insights from the rhesus macaque genome. Science 316: 222-234 [cover article]
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Mikkelsen, T.S., M. J. Wakefield, B. Aken, C. T. Amemiya, J. L. Chang, S. Duke, M. Garber, A. J. Gentles, L. Goodstadt, A. Heger, J. Jurka, M. Kamal, E. Mauceli, S. M. J. Searle, T. Sharpe, M. L. Baker, M. A. Batzer, P. V. Benos, K. Belov, M. Clamp, A. Cook, J. Cuff, R. Das, L. Davidow, J. E. Deakin, M. J. Fazzari, J. L. Glass, M. Grabherr, J. M. Greally, W. Gu, T. A. Hore, G. A. Huttley, R. L. Jirtle, E. Koina, J. T. Lee, S. Mahony, M. A. Marra, R. D. Miller, R. D. Nicholls, M. Oda, A. T. Papenfuss, Z. E. Parra, D. D. Pollock, D. A. Ray, J. E. Schein, T. P. Speed, K. Thompson, J. L. VandeBerg, C. M. Wade1, J. A. Walker, P. D. Waters, C. Webber, J. R. Weidman, X. Xie, M. C. Zody, Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, J. A. Marshall Graves, C. P. Ponting, M. Breen, P. B. Samollow, E. S. Lander and K. Lindblad-Toh (2007) Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447: 167-178 [cover article] |
* These authors contributed equally to this work.
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Sue G.
Bartlett, Associate Professor; Ph.D., Duke
University, 1978. sbartle@lsu.edu
Chloroplast biogenesis, especially
the synthesis and transport of chloroplast proteins.
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Floyd, Z. E. and S. G. Bartlett.
1995. Nucleotide Sequence of a cDNA Encoding Eukaryotic
Initiation Factor 5 (Accession No. L47221) In Bean.
Plant Physiol. Plant Gene Register PGR95-092.
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Bracey, M. H. and S. G. Bartlett.
1995. Sequence Of a cDNA Encoding Carbonic Anhydrase
From Barley. Plant Physiol.108:433-434.
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| Bracey, M. H., J. Christiansen, P.
Tovar, S. P. Cramer and S. G. Bartlett. 1994. Spinach
Carbonic Anhydrase: Investigation of the Zinc-Binding
Ligands by Site-Directed Mutagenesis, Elemental
Analysis, and EXAFS. Biochemistry
33:13126-13131. |
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John R.
Battista, Associate Professor; Ph.D., Wayne
State University, 1986. jbattis@lsu.edu
DNA repair and mutagenesis in E.
coli and Deinococcus radiodurans.
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Battista, J. R., Earl, A. M., and
Park, M-J, 1999. Why is Deinococcus radiodurans so
resistant to ionizing radiation? Trends Microbiol.
7:362-365.
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Battista, J. R., 1997. Against all
odds: The survival strategies of Deinococcus
radiodurans. Ann. Rev. Microbiol. 51:203-224.
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| Mattimore, V. and Battista, J. R.,
1996. Radioresistance of Deinococcus radiodurans:
Functions Necessary to Survive Ionizing Radiation Are
Also Necessary to Survive Prolonged Desiccation. J.
Bacteriol. 178:633-637. |
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Terry M.
Bricker, Moreland Family Professor and Interim
Chair; Ph.D., Miami University (Ohio), 1981. btbric@lsu.edu
Protein-Protein Interactions in
Membrane Protein Complexes. Structure and Function in
Photosystem II, Proteomics of the Chloroplast Lumen
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Wu, J., Masri, N., Lee, W.,
Frankel, L.K. and T.M. Bricker, 1999. "Directed Random
Mutagenesis in the Large Extrinsic Loop of the CP 47
Protein of Photosystem II." Plant Molecular Biology
39,381-386.
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Knoepfle, N., Bricker, T.M., and
Putnam-Evans, C., 1999. "Site-Directed Mutagenesis of
the Basic Residues 305R and 342R in the CP 43 Protein of
Photosystem II Affects Oxygen-Evolving Activity in
Synechocystis 6803." Biochemistry 38,1582-1588.
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| Zubrzycki, I.Z., Frankel, L.K.,
Russo, P.S. and T.M. Bricker, 1998. "Hydrodynamic
Studies on the Extrinsic "33 kDa" Protein of Photosystem
II." Biochemistry 37,13553-13558. |
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Richard C. Bruch, Associate Professor; Ph.D., University of
Delaware, 1982. rbruch@lsu.edu
Molecular mechanisms mediating
signal transduction in peripheral olfactory neurons.
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Medler, K. F., Tran, H. N., Parker,
J. M., Caprio, J. and Bruch, R. C., 1998. Metabotropic
glutamate receptor expression in olfactory receptor
neurons from channel catfish, Ictalurus punctatus. J.
Neurobiol. 35, 94-104.
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Bruch, R. C., Medler, K. F., Tran,
H. and Hamlin, J. A. 1997. G-protein Beta Gamma-submit
genes expressed in olfactory receptor neurons.
Chem.Senses. 22:587-592.
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| Bruch, R. C., Kang, J., Moore, M.
and Medler, K. F. 1997. Protein kinase C and receptor
kinase gene expression in olfactory receptor neurons. J.
Neurobiol. 33: 387-394. |
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Simon H.
Chang, Professor; Ph.D., Oklahoma State
University, 1966. schang@lsu.edu
Molecular structure and function of
metabolic enzymes; regulation of tissue-specific
expression; mechanisms of mutagenesis.
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Auzat, I., Bynes, M., Grrel, J-R.
and Chang, S.H. 1995. The role of residue 161 in the
allosteric transitions of two bacterial
phosphofructokinase. Biochemistry 34, 7062-7068.
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Zbu, X., Byrnes, M., Nelson, J.W.
and Chang, S.H. 1995. The role of glycine-121 in the
allosteric behavior of phosphofructokinase form B.
stearothermophilus. Biochemistry 34, 2560-2565.
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| Li, J., Zhu, X., Byrnes, M. Nelson,
J.W. and Chang, S.H. (1993) Site-directed mutagenesis of
rabbit muscle phosphofructokinase cDNA: Mutations at
Glutamine 200 affect the allosteric properties of the
enzyme. J. Biol. Chem. 268, 24599-24606. |
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Brent C. Christner, Assistant Professor; Ph.D., Ohio State
University, 2002. xner@lsu.edu
Microbial ecology, physiology, and diversity; molecular biology; microbiology of the cryosphere.
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Christner, B.C., J.A. Mikucki, C.M. Foreman, J. Denson, and J.C. Priscu. 2005. Glacial ice cores:
a model system for developing extraterrestrial decontamination protocols. Icarus, 174:572-584.
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Christner, B.C., E. Mosley-Thompson, L.G. Thompson, and J.N. Reeve. 2005. Recovery and
identification of bacteria from polar and non-polar glacial ice. In S. O. Rogers and J. Castello (eds),
Life in Ancient Ice, pp. 209-227. Princeton University Press, Princeton, New Jersey.
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Royston-Bishop, G., J.C. Priscu, M. Tranter, B.C. Christner, M.J. Siegert, and V. Lee. 2005.
Incorporation of particulates
into accreted ice above Subglacial Lake Vostok, Antarctica. Annals of Glaciology 40:145-150.
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| Priscu, J.C., and B.C. Christner. 2004. Earth’s icy biosphere. In Bull, Alan T. (ed.),
Microbial Diversity and Bioprospecting, pp. 130-145. American Society for Microbiology, Washington, D.C. |
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Patrick
DiMario, Associate Professor; Ph.D., Indiana
University, 1985. pdimari@lsu.edu
Study of proteins involved with
ribosome biogenesis and nucleolar structure.
Posttranslational phosphorylation or methylation of
individual nucleolin peptide domains.
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Zhu, Y., Lu, D., and DiMario, P.J.
(1999). Nucleolin, defective for MPF phosphorylation,
localizes normally during mitosis and nucleologenesis.
Histochem. Cell Biol. 111:477-487.
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Shah, S.B., Terry, C.D., Wells,
D.A., and DiMario, P.J. (1996). Structural changes in
oocyte nucleoli of Xenopus laevis during oogenesis and
meiotic maturation. Chromosoma 105:111-121.
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| Heine, M.A., Rankin, M.L., and
DiMario, P.J. (1993). The Gly/Arg rich (GAR) domain of
Xenopus nucleolin facilitates in vitro nucleic acid
binding and in vivo nucleolar localization. Molec. Biol.
Cell 4:1189-1204. |
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Huangen Ding, Associate Professor;
Ph.D., University of Pennsylvania, 1995. hding@lsu.edu
Regulatory function and metabolism
of iron sulfur proteins during oxidative stress.
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Rogers, P. A. & Ding, H. (2001)
L-cysteine-mediated destabilization of dinitrosyl iron
complexes in proteins. J. Biol. Chem. 276,
30980-30986.
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Ding, H. & Demple, B. 1998.
Thiol-mediated Disassembly and Reassembly of [2Fe-2S]
clusters in the Redox-regulated Transcription Factor
SoxR, Biochemistry 37, 17280-17286.
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| Ding, H. & Demple, B. 1997. In
vivo Kinetics of a Redox-Regulated Transcriptional
Switch. Proc. Natl. Aca. Sci. USA., 94;
8445-8449. |
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William Doerrler, Assistant Professor;
Ph.D. University of Texas Southwestern Medical Center, 1999.
wdoerr@lsu.edu
Membrane biogenesis in E. coli.
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Doerrler WT and Raetz CR. ATPase activity of the MsbA
lipid flippase of Escherichia coli. J Biol Chem 277; 36697-36705,
2002.
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Trent MS, Ribeiro AA, Doerrler WT, Lin S, Cotter R, Raetz
CR. Accumulation of a polyisoprene-linked amino sugar
in polymyxin resistant Salmonella typhimurium and Escherichia
coli. Structural characterization and transfer to lipid
A in the periplasm. J Biol Chem 276; 43132-43144, 2001.
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| Doerrler WT, Reedy MC, Raetz CR. An Escherichia coli
mutant defective in lipid export. J Biol Chem 276; 11461-11464,
2001. |
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David Donze, Assistant Professor;
Ph.D. The University of Alabama at Birmingham, 1996. ddonze@lsu.edu
Chromatin Structure and Gene
Expression.
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The Boundaries of the Silenced HMR
Domain in Saccharomyces cerevisiae. David Donze,
Christopher R. Adams, Jasper Rine, and Rohinton T.
Kamakaka Genes and Development, Vol. 13, 698-708
(1999).
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RNA Polymerase III and Polymerase
II Promoter Complexes are Heterochromatin Barriers in
Saccharomyces cerevisiae. David Donze and Rohinton T.
Kamakaka The EMBO Journal, Vol. 20 No. 3, 520-531
(2001).
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| Sir2p is a Component of Two
Nucleosome Binding Complexes that Differ in Deacetylase
Activity. Sonja Ghidelli, David Donze, Christopher R.
Adams, and Rohinton T. Kamakaka Manuscript
submitted. |
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Randy C.
Gayda, Associate Professor; Ph.D., University of
Chicago, rgayda@lsu.edu
Genetic and biochemical regulation
of bacterial cell division in E. coli.
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Gayda, R.C. and X. Shao. 1993.
Identification of ftsA-homologs in procaryotes. J.
Cellular biochemistry, supplement 17C.
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Wang, H., M.C. Henk and R. Gayda.
1993. Over expression of ftsA induces large bulges at
the septal regions in Escherichia coli. Cur. Microbiol.
26:175-181.
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| Wang, H. and R.C. Gayda. 1992.
Quantitative determination of ftsA at different growth
rates in Escherichia coli using monoclinal antibodies.
Molecular Microbiology 6:2517-2524. |
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Anne Grove, Associate Professor;
Ph.D., University of Copenhagen, Denmark, 1990. agrove@lsu.edu
Protein-nucleic acid interactions
and sequence-dependent DNA bendability, analyzed in the
context of the yeast RNA polymerase III.
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Grove, A., Kassavetis, G. A.,
Johnson, T. E. & Geiduschek, E. P. 1999. The RNA
polymerase III-recruiting factor TFIIIB induces a DNA
bend between the TATA box and the transcriptional start
site. J. Mol. Biol. 285, 1429-1440.
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Grove, A., Galeone, A., Yu, E.,
Mayol, L. & Geiduschek, E. P. 1998. Affinity,
stability and polarity of binding of the TATA binding
protein governed by flexure at the TATA box. J. Mol.
Biol. 282, 731-73.
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| Grove, A., Figueiredo, M. L.,
Galeone, A., Mayol, L. & Geiduschek, E. P. 1997.
Twin hydroxymethyluracil-A base pair steps define the
binding site for the DNA-bending protein TF1. J. Biol.
Chem. 272, 13084-13087. |
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Hale-Donze, Hale, Assistant
Professor Ph.D., University of Alabama at
Birmingham,1997. hhaled1@lsu.edu
Infection and Immunity.
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Hale-Donze, H., Greenwell-Wild, T.,
Mizel, D., Doherty, T.M., Chatterjee, D., Orenstein,
J.M., and Wahl, S.M. (2002) Mycobacterium avium complex
(MAC) promotes recruitment of monocyte hosts for HIV-1
and bacteria. Journal of Immunology, 169:3854-62.
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Wahl, S. M., Greenwell-Wild, T.,
Peng, G., Hale-Donze, H., Doherty, T. M., Mizel, D., and
J. M. Orenstein. (1998) Mycobacterium avium complex
(MAC) augments macrophage HIV-1 production and increases
CCR5 expression. Proceedings of the National Academy of
Science, U.S.A. 95:12574-9.
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| Ashcroft, G.S., Lei, K., Jin, W.,
Longenecker, G., Kulkarni, A.B., Greenwell-Wild, T.,
Hale-Donze, H., McGrady, G., Song, X-Y., and S.M. Wahl.
(2000) Secretory leukocyte protease inhibitor (SLPI)
mediates non-redundant functions necessary for normal
wound healing. Nature Medicine. 6:1147-1153
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Steven C.
Hand, Professor and Chairman Ph.D., Oregon State
University, 1980. shand@lsu.edu
Bioenergetics, molecular
physiology, environmental control of gene expression,
comparative biochemistry.
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Podrabsky, J. and S.C. Hand (2000)
Depression of protein synthesis during diapause in
embryos of the annual killifish, Austrofundulus
limnaeus. Physiol. Biochem. Zool. (in press).
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Gnaiger, E., Mendez, G., and S.C.
Hand (2000) High phosphorylation efficiency and
depression of uncoupled respiration in mitochondria
under severe hypoxia. Proc. Natl. Acad. Sci. USA 97:
11080-11085.
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| van Breukelen, F., Maier, R. and
S.C. Hand (2000) Depression of nuclear transcription and
extension of mRNA half-life under anoxia in Artemia
franciscana embryos. J. Exp. Biol. 203:
1123-1130. |
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Craig M.
Hart, Assistant Professor; Ph.D., Cornell
University, 1989. chart4@lsu.edu
Chromosome Organization, Chromatin
Structure and Gene Expression.
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Hart, C.M., Cuvier, O., and
Laemmli, U.K. 1999. Evidence for an antagonistic
relationship between the boundary element-associated
factor BEAF and the transcription factor DREF.
Chromosoma 108:375-383.
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Cuvier, O., Hart, C.M., and
Laemmli, U.K. 1998. Identification of a class of
chromatin boundary elements. Mol. Cell. Biol.
18:7478-7486.
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| Hart, C.M. and Laemmli, U.K. 1998.
Facilitation of chromatin dynamics by SARs. Curr. Opin.
Genet. Dev. 8:519-525. |
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Brooks A. Keel,
Vice Chancellor, Office of Research and Economic
Development, Ph.D. bkeel@lsu.edu
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Keel BA, Schalue TK (2000) Correlation of the bovine cervical mucus penetration test with
human sperm characteristics in 1406 ejaculates. Arch Androl 44:109-115.
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Keel BA, Quinn P, Schmidt CF, Serafy Jr NT, Serafy NT, Schalue TK (2000) Results of the American
Association of Bioanalysts national proficiency testing program in andrology. Hum Reprod 15:680-686.
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| Keel BA, Stembridge TW, Pineda G, Serafy NT Sr. (2002) Standardization in the performance of the
semen analysis among laboratories in the United States. Fertil Steril 78:603-608. |
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Roger A.
Laine, Professor; Ph.D., Rice University, 1970.
rlaine@lsu.edu
Bioactivity and structure of
complex carbohydrates, microbial diagnostics, termite
chemical effectors, analysis and pharmacophores.
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Laine, Roger A. and Lo, Jennifer
WC, 1999. "Method for Detecting Eubacteria in Biological
Samples with Catalytically Inactive Murein Binding
Enzymes" U.S. Patent Serial No. 5,935,804.
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Chen J, Henderson G, Laine RA,
1998. "Termites fumigate their nests with napthalene"
Nature 392: 558.
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| Wu, M. H. and Laine, R. A. , 1999.
Sequence of the Vibrio parahaemolyticus gene for
cytoplasmic N,N'-diacetylchitobiase and homology with
related enzymes , J. Biochemistry (Tokyo)125:
1086-1092. |
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John C.
Larkin, Assistant Professor; Ph.D., Carnegie
Mellon University, 1985. jlarkin@lsu.edu
Developmental genetics, cell
differentiation, cell cycle, plant biology.
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Larkin, J. C., J. D. Walker, A. C.
Bolognesi-Winfield, J. C. Gray, and A. R. Walker. 1999.
"Allele-specific interactions between ttg and gl1 during
trichome development in Arabidopsis thaliana." Genetics
151: 1591-1604.
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Larkin, J. C., M. David Marks, J.
Nadeau, and F. Sack. 1997. "Epidermal cell fate and
patterning in leaves." Plant Cell 9: 1109-1120.
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| Larkin, J. C., Young, N., Prigge,
M., and Marks, M. 1996. "The control of trichome spacing
and number in Arabidopsis". Development 122,
997-1005. |
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Yong-Hwan
Lee, Assistant Professor ; Ph.D., State
University of New York – Stony Brook.
Structure/function studies of the
metabolic regulator proteins and their regulatory
mechanisms.
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Lee YH, Nadaraia S, Gu D, Becker
DF, Tanner JJ. Structure of the proline dehydrogenase
domain of the multifunctional PutA flavoprotein. Nat
Struct Biol. 2003; 10: 109-14.
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Lee YH, Li Y, Uyeda K, Hasemann CA.
Tissue-specific structure/function differentiation of
the liver isoform of
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. J
Biol Chem. 2003; 278: 523-30.
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Lee YH, Dorwart MR, Hazlett KR,
Deka RK, Norgard MV, Radolf JD, Hasemann CA. The crystal
structure of Zn(II)-free Treponema pallidum TroA, a
periplasmic metal-binding protein, reveals a closed
conformation. J Bacteriol. 2002; 184: 2300-4.
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| Lee YH, Deka RK, Norgard MV, Radolf
JD, Hasemann CA. Treponema pallidum TroA is a
periplasmic zinc-binding protein with a helical
backbone. Nat Struct Biol. 2002; 6: 628-33. |
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Vince J.
LiCata, Assistant Professor; Ph.D., Johns
Hopkins University, 1990. licata@lsu.edu
Protein structure and function;
energy management in proteins; the role of water and
solvent in protein function and stability.
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LiCata, V.J., Burz, D.S., Moerke,
N.J., and Allewell, N.M., 1998. The Magnitude of the
Allosteric Conformational Transition of Aspartate
Transcarbamylase is altered by Mutations, Biochemistry
37,17381-17385.
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LiCata, V.J. and Allewell, N.M.,
1998. Measuring Hydration Changes of Proteins in
Solution: Applications of Osmotic Stress and
Structure-Based Calculations, Methods in Enzymology,
295, 42-62.
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| LiCata, V.J. and Bernlohr, D.A.,
1998. Surface Characteristics of Adipocyte Lipid Binding
Protein. Response to Lipid Binding and Comparison with
Homologous Proteins, Proteins: Structure, Function, and
Genetics, 33:577-589. |
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Thomas S.
Moore, Professor; Ph.D., Indiana University,
1970. btmoor@lsu.edu
Regulation of membrane lipid
synthesis.
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Tang, F and TS Moore. 1997. Enzymes
of the primary phosphatidylethanolamine biosynthetic
pathway in castor bean endosperm. Developmental profiles
and partial purification of the mitochondrial CTP:
ethanolaminephophate cytidylyltransferase. Plant
Physiol. 115: 1589-1597.
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Chapman, K. D. and T. S. Moore.
1994. Isozymes of cottonseed microsomal N-
acylphosphatidylethanolamine synthase: Detergent
solubilization and electrophoretic separation of active
enzymes with different properties. Biochem. Biophys.
Acta 1211:29-36.
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| Chapman, K. D. and T. S. Moore.
1993. Catalytic properties of a newly discovered
acyltransferase that synthesizes
N-acylphosphatidylethanolamine in cottonseed (Gossypum
hirsutum L.) microsomes. Plant Physiol.
102:761-769. |
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James V.
Moroney, Professor; Ph.D., Cornell University,
1982. btmoro@lsu.edu
Photosynthesis and
bioenergetics.
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Moroney, J.V., and Somanchi A.
1999. How do microalgae concentrate CO2 to increase the
efficiency of photosynthetic carbon fixation? Plant
Physiol 119: 9-16.
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Karlsson, J., Clarke, A.K., Chen,
Z.-Y., Hugghins, S.Y., Park, Y.-I., Husic, H.D.,
Moroney, J.V. and Samuelsson, G. 1998. A novel
"alpha-type" carbonic anhydrase associated with the
thylakoid membrane in Chlamydomonas reinhardtii is
required for growth at ambient air. EMBO J.
17:1208-1216.
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| Borkhsenious, O.N., Mason, C.B. and
Moroney, J.V. 1998. The intracellular localization of
ribulose-1,5-bisphosphate carboxylase/oxygenase in
Chlamydomonas reinhardtii. Plant Physiol.
116:1585-1591. |
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Marcia
Newcomer, Professor, Ph.D., Rice University,
1979. newcomer@lsu.edu
Protein Crystallography.
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Pakhomova, S., Kobayashi, M., Buck,
J. and Newcomer, M.E.: A Helical Lid Converts a
Sulfotransferase to a Dehydratase. Nature Structural
Biology 8, 447-451 (2001).
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Lamb, A.L. and Newcomer, M.E.: The
Structure of Retinal Dehydrogenase Type II: Implications
for Retinal Specificity. Biochemistry 38, 6003-6011
(1999).
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| Naylor, H.M. and Newcomer, M.E.:
The Structure of Human Retinol Binding Protein (RBP)
with its Carrier Protein Transthyretin Reveals an
Interaction with the Carboxy Terminus of RBP.
Biochemistry 38, 2647- 2653 (1999). |
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Gregg S. Pettis, Associate
Professor; Ph.D., University of Missouri, 1989. gpettis@lsu.edu
Genetics and molecular biology of
conjugation in the bacterial genus Streptomyces;
biological control and pathogenesis of the sweetpotato
pathogen Streptomyces ipomoeae.
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Pettis, G.S., N. Ward, and K.L.
Schully. 2001. Expression characteristics of the
transfer-related kilB gene product of Streptomyces
plasmid pIJ101: implications for the plasmid spread
function. J. Bacteriol. 183: 1339-1345.
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Ducote, M.J., S. Prakash, and G.S.
Pettis. 2000. Minimal and contributing sequence
determinants of the cis-acting locus of transfer (clt)
of streptomycete plasmid pIJ101 occur within an
intrinsically curved plasmid region. J. Bacteriol. 182:
6834-6841.
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| Clark, C. A., C. Chen, N .
Ward-Rainey, and G. S. Pettis. 1998. Diversity within
Streptomyces ipomoeae based on inhibitory interactions,
rep-PCR, and plasmid profiles. Phytopathology
88:1179-1186. |
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Kirsten Prüfer ,
Assistant Professor; Ph.D., Friedrich-Schiller University Jena, Germany 1995.
kprufer@lsu.edu
Cell biology of nuclear
receptors, trafficking, nuclear import and export,
molecular endocrinology, biochemistry, molecular biology
.
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Kirsten Prüfer, Julia Barsony:
Retinoid X Receptor Dominates the Nuclear Import and
Export of the Unliganded Vitamin D Receptor. Molecular
Endocrinology 16 (2002) 1738-1751.
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Julia Barsony, Kirsten Prüfer:
Vitamin D Receptor and Retinoid X Receptor Interactions
in Motion. Vitamins and Hormones 65 (2002) 345-376. .
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| Kirsten Prüfer, Claudia Schröder,
Krisztina Hegyi, Julia Barsony: Enhanced Degradation of
Retinoid X Receptors in Osteosarcoma Cells Prevents the
Antiproliferative Effects of Calcitriol and Retinoic
Acid. Molecular Endocrinology 16 (2002)
961-976. |
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Jacqueline Stephens, Professor;
Ph.D., East Carolina University School of Medicine. 1992.
jsteph1@lsu.edu
Cell biology; insulin action in
adipocytes and the regulation of transcription factors
during adipogenesis.
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Stephens, J. M., Morrison, R.F.,
Wu, Z., and Farmer, S.R. 1999. PPAR ligand dependent
induction of STATs 1 and 5 during adipogenesis. Biochem.
Biophys. Res. Commun. 262, 216-222.
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Stephens, J. M., Lumpkin, S. J. and
Fishman, J.B. 1998. Activation of STATs 1 and 3 by LIF,
OSM, and IFN in Adipocytes. J. Biol. Chem. 273,
31408-31416.
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| Stephens, J.M., Lee, J., and Pilch,
P.F. 1997. TNF-induced insulin resistance in 3T3-L1
adipocytes is accompanied by a loss of IRS-1 and GLUT4
expression without a loss of insulin receptor-mediated
signal transduction. J. Biol. Chem. 272,
971-976. |
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Grover L.
Waldrop, Associate Professor; Ph.D, State
University of New York (Buffalo), 1988. gwaldro@lsu.edu
Kinetic and chemical mechanisms of
enzymatic reactions.
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Function of Escherichia coli Biotin
Carboxylase Requires Catalytic Activity of Both Subunits
of the Homodimer. Janiyani, K., Bordelon, T., Waldrop,
G.L. and Cronan, J.E. (2001) J. Biol. Chem., 276,
29864-29870.
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Site-directed Mutagenesis of ATP
Binding Residues of Biotin Carboxylase: Insight into the
Mechanism of Catalysis. Sloane, V., Blanchard, C.Z.,
Guillot, F. and Waldrop, G.L. (2001) J. Biol. Chem.,
276, 24991-24996.
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Movement of the Biotin Carboxylase
B-Domain as a Result of ATP-Binding. Thoden, J.B.,
Blanchard, C.Z., Holden, H.M. and Waldrop, G.L. (2000)
J. Biol. Chem., 275, 16183-16190.
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Do Cysteine 230 and Lysine 238 of
Biotin Carboxylase Play a Role in the Activation of
Biotin? Levert, K.L., Lloyd, R.B. and Waldrop, G.L.
(2000) Biochemistry 39, 4122-4128.
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| Synthesis of a Reaction
Intermediate Analog of Biotin-Dependent Carboxylases via
a Selective Derivatization of Biotin. Amspacher, D.R.,
Blanchard, C.Z., Fronczek, F.R., Saraiva, M.C., Waldrop,
G.L. and Strongin, R.M. (1999) Organic Letters, 1,
99-102. |
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Tin-Wein Yu, Assistant Professor;
Ph.D. University of East Anglia, John Innes Institute, 1995. yu@lsu.edu
Functional genetics of microbial metabolites and structural diversity of natural products.
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P. Spiteller, L. Bai, G. Shang, B. J. Carroll, T. -W.
Yu, H. G. Floss The post-polyketide synthase modification
steps in the biosynthesis of the antitumor agent ansamitocin
by Actinosynnema pretiosum. J Am Chem Soc. 125, 14236-7
(2003)
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T. -W. Yu, L. Bai, D. Clade, D. Hoffmann, S. Toelzer,
K. Q. Trinh, J. Xu, S. J. Moss, E. Leistner, H. G. Floss
The biosynthetic gene cluster of the maytansinoid antitumor
agent ansamitocin from Actinosynnema pretiosum. Proc Natl
Acad Sci U S A. 99, 7968-73 (2002).
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B. J. Carroll, S. J. Moss, L. Bai, Y Kato, S. Toelzer,
T. -W. Yu, H. G. Floss Identification of a set of genes
involved in the formation of the substrate for the incorporation
of the unusual "glycolate" chain extension unit
in ansamitocin biosynthesis. J Am Chem Soc. 124, 4176-7
(2002).
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Y. Kato, L. Bai, Q. Xue, W. P. Revill, T. -W. Yu, H.
G. Floss Functional expression of genes involved in the
biosynthesis of the novel polyketide chain extension unit,
methoxymalonyl-acyl carrier protein, and engineered biosynthesis
of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. J Am
Chem Soc 124, 5268-9 (2002).
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K. Arakawa, R. Müller, T. Mahmud,
T. -W. Yu, H. G. Floss Characterization of the early stage
aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic
acid: the RifN protein specifically converts kanosamine
into kanosamine 6-phosphate. J Am Chem Soc. 124, 10644-5
(2002). |
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Wayne Zhou, Associate Professor;
zhouw@lsu.edu
Structure and Function of protein tyrosine phosphatases; Structure and Function of the phox (PX) domain-containing proteins.
Identifying potential biomarkers for cancer diagnosis by using antibody microarray staining.
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Yang, J., Liu, L., He, D., Song,
X., Liang, X., Zhao, Z. and Zhou, G. W. (2003). “Crystal
Structure of Human protein tyrosine phosphatase SHP-1”
J. Biol. Chem. 278, 6516-6520.
s
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Wu, C., Sun, M., Liu, L. and Zhou,
G. W. (2003) “The function of protein tyrosine phosphatase
SHP-1 in cancer.” Gene. 306, 1-12. (Review).
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Zhan, Y., Virbasius, J. V., Song, X., Pomerleau, D. P.,
Czech, M. P and Zhou, G. W. (2002) “p40phox PX domain
and p47phox PX domain of NADPH oxidase target to membrane
via direct and indirect recruitment by phosphoinositides”
J. Biol. Chem.. 277, 4512-4518.
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Y. Kato, L. Bai, Q. Xue, W. P. Revill, T. -W. Yu, H.
G. Floss Functional expression of genes involved in the
biosynthesis of the novel polyketide chain extension unit,
methoxymalonyl-acyl carrier protein, and engineered biosynthesis
of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. J Am
Chem Soc 124, 5268-9 (2002).
|
Virbasius, J. V., Song, X., Pomerleau,
D. P., Zhan, Y., Zhou, G. W. and Czech, M. P. (2001) “Activation
of the Akt-related cytokine-independent survival kinase
requires interaction of its phox domain with endosomal
phosphatidylinositol 3-phosphate.” Proc. Nat. Acad.
Sci. 98, 12908-12913.
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